Brain tumour clinical trial title

Glutamate Dysfunction in Gliomas, V1.0 (Study ID: 35345)

Brain tumour type

Anaplastic glioma,  Anaplastic oligodendroglioma,  Glioblastoma,  Glioma, 



Seizures are a frequent and serious problem for patients with brain tumours and are often not controlled with current best medical and surgical treatments. There are approximately 4,000 new cases of patients certain type of brain tumour in the UK each year. Many of these patients suffer from ongoing seizures due to the resistance of the tumours associated seizures to anti-convulsant drugs. A better understanding of the mechanisms of how seizures associated with brain tumours arise will ultimately lead to the generation of better anti-convulsant drugs to treat these seizures. In this study we want to look a number of factors that could explain the underlying mechanisms of these seizures. This study, supported by Medical Research Council, will look at specific changes in the brains of patients with tumour associated seizures. We will use non-invasive techniques to measure the electrical excitability of the brain and measure the levels of transmitter that causes excitation to occur. This pilot observational case-control study will test and compare a group of patients consisting of individuals with a certain type of brain tumour (glioma) who exhibit or do not exhibit seizures. The outcome of this research will help us to develop non-invasive markers to evaluate how good new treatments will be in terms of reducing seizures in patients with brain tumours.

Date added: 12th January 2019

Open/Closed: Open

Trial ends: December 2018


The Newcastle upon Tyne Hospitals NHS Foundation Trust

Contact details

Mark Cunningham :
Freeman Road
High Heaton
Newcastle Upon Tyne

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